Brown Lab

Publications

Peer-reviewed Publications

  1. Brown A*, Zhang H, Lopez P, Pardo C, Gartner S. In vitro modeling of the HIV-macrophage reservoir. J. of Leukocyte Biol. 2006;80(5):1127-1135. First report to identify and characterize at the molecular level latent and persistent populations of HIV-infected macrophages.
  2. Brown A. Use of a macrophage-tropic GFP-tagged human immunodeficiency virus type 1 (HIV-1) to study viral reservoirs. Methods in Mol. Biol 2009;515:165-175.
  3. Grab D, Garcia-Garcia JC, Nikolskaia OV, Kim YV, Brown A, Pardo CA, Zhang Y, Becker KG, Wilson BA, de A Lima AP, Scharfstein J, Dumler JS. Protease activated receptor signaling is required for African typanosome traversal of human brain microvascular endothelial cells. PLOS Neglected Tropical Diseases 2009: 3(7):e479. Isolated trypanosome infected human brain microvascular endothelial cells using laser capture microdissection.
  4. Hammoud DA, Endres CJ, Hammond E, Uzuner O, Brown A, Nath A, Kaplin AI, Pomper MG. Imaging serotonergic transmission with [(11)C]DASB-PET in depressed and non-depressed patients infected with HIV. Neuroimage 2009; 49(3):2588-2595. Performed genotyping of the serotonin transporter.
  5. Brown A, Shiramizu B, Nath A, Wojna V. Translational research in neuroAIDS: a neuroimmune pharmacology-related course. J. Neuroimmune Pharmacol. 2011; 6(1):80-88.
  6. Brown A*, Islam T, Adams R, Nerle S, Kamara M, Eger C, Marder K, Cohen B, Schifitto G, McArthur J, Sacktor N, Pardo C. Osteopontin enhances HIV-1 replication and is increased in the brain and cerebrospinal fluid of HIV-infected individuals. J. Neurovirology 2011; 17(4):382-392. PMC3331788. Study that launched data for first R01.
  7. Brown A*, Sacktor N, Marder K, Cohen B, Schifitto G, Skolasky R, Creighton J, Guo L, McArthur J. CCL3L1 gene copy number in individuals with and without HIV-associated neurocognitive disorder. Current Biomarker Findings 2012; 2: 1-6. PMC3693394.
  8. Brown A*.  Osteopontin: A Key Link Between Immunity, Inflammation and the Central Nervous System.  Translational Neuroscience 2012; 3(3):288-294.
  9. Gamaldo CE, Gamaldo A, Creighton J, Salas RE, Selnes OA, David PM, Mbeo G, Parker BS, Brown A, McArthur JC, Smith MT. Evaluating sleep and cognition in HIV. J. Acquir. Immune Defic. Syndr 2013; 63(5):609-616.
  10. Babu R, Brown A*. A consensus surface activation marker signature is partially dependent on human immunodeficiency Virus Type I Nef expression within productively infected macrophages. Retrovirology 2013; 10:155. First study to characterize the cell surface phenotype of productively HIV-infected human cultured macrophages. Open acess article marked “highly accessed”.
  11. Lucas C-H, Calvez M, Brown A*. Altered subcellular localization of the NeuN/Rbfox3 RNA splicing factor in HIV-associated neurocognitive disorders (HAND). Neuroscience Letters 2014; 558:97-102. PMC3880598. First study to report a unique observation on the neuron-specific marker NeuN in brain tissue from HIV-infected subjects with cognitive impairment.
  12. Eger C, Cirelli K, Budiaman J, Brown A*. Non-contiguous protein interaction domains in osteopontin contribute to enhance HIV-1 replication. J. Human Virol. and Retrovirol 2014; 1(1):00003. DOI: 10.15406/jhvrv.2014.01.00003;PMC6879059
    First report on the molecular genetic analyses to map osteopontin functional domains.
  13. Silva K., Hope-Lucas C, White T, Hariston T, Rameau T, Brown A*. Cortical neurons are a prominent source of the proinflammatory cytokine osteopontin in HIV-associated neurocognitive disorders (HAND). J. Neurovirology 2015; 21(2):174-185. PMC4372685. First quantitative analyses of osteopontin expression on human brain autopsy tissue.
  14. Brown A*.  Understanding the MIND Phenotype: Macrophage/Microglial Inflammation in Neurocognitive Disorders Related to Human Immunodeficiency Virus Infection.  Clinical Translational Medicine 2015; 4:7 DOI 10. 1186/s40169-015-0049-2.
  15. Saylor D, Dickens A, Sacktor N, Haughey N, Slusher B, Pletnikov M, Brown A, Volsky D, and McArthur J. HIV-Associated Neurocognitive Disorders: Emerging Concepts in Pathogenesis and Therapy. Nature Reviews Neurol 2016;12(4):234-248.
  16. Calvez M, Hseeh G, Benzer S, and Brown A*. Osteopontin counters HIV-induced neuronal injury through the activation of mTOR and beta-integrin signaling. J. Neurovirology 2019; 25(3):384-396.DOI : 10.1007/s13365-019-00729-yNJIV-D-18-00140.1. Identified mechanistic basis for the neuroprotective effect of osteopontin.
  17. Lei J, Vermillion MS, Jia B, Xie H, Xie L,McLane MW, Sheffield JS, Pekosz A, Brown A, Klein SL, and Burd I. IL-1 receptor antagonist therapy mitigates placental dysfunction and perinatal injury following Zika virus infection. J. Clinical Investigation Insight 2019. 10.1172/jci.insight.122678. Research collaboration-grew virus and infected microglia.
  18. Mohamed M, Skolasky RL, Zhou Y, Ye W, Brasic JR, Brown A, Pardo CA, Barker PB, Wong DF, and N Sacktor. Beta-amyloid (Abeta) uptake by PET imaging in older HIV+ and HIV- individuals. J. Neurovirology 2020; https://doi.org/10.1007/s13365-020-00836-1. Research collaboration-conducted genotyping and analyses. 
  19. Mahmud F, Boucher T, Liang SJ, and Brown A*. Osteopontin and integrin mediated modulation of post-synapses in HIV  envelope glycoprotein exposed hippocampal neurons. Brain Sciences2020; 10(6):346  https://doi.org/10.3390/brainsci10060346. PMID: 32512754
  20. Mahmud F, Du Y, Greif E, Boucher T, DannalsRF, MathewsWB, PomperMG, Sysa-ShahP, Metcalf PateKA, LyonsC, CarlsonB, Chacona M, and Brown A*. Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection. J. Neuroinflammation. 17: 273 (2020) doi: 10.1186/s12974-020-01949-4. First report to demonstrate that HIV increases neuroinflammation as determined by neuroimaging in a mouse model.
  21. Mahmud F, Du Y, Greif E, Boucher T, Metcalf PateKA, LyonsC, CarlsonB, and Brown A*. Complex interactions between human immunodeficiency virus type-1, sex, and osteopontin influence viral and leukocyte persistence in tissues. F. Virology (2021) https://doi.org/10.3389/fviro.2021.690360
  22. Willis A, Skolarus LE, Faigle R, Menon U, Redwine H, Brown AM, Felton E, Mendizabal A, Nath A, Jensen F, McArthur JC. Strengthened through Diversity: A Blueprint for Organizational Change. Ann Neurol. 2021 Jul 7. doi: 10.1002/ana.26165.
  23. Boucher T, Liang SJ, and Brown A*. Advancing Basic and Translational Research to Deepen Understanding of the Molecular Immune-Mediated Mechanisms Regulating Long-Term Persistence of HIV-1 in Microglia in the Adult Human Brain. J Leukocyte Biol. (2022) 112:1223-1231.
  24. Yim A, Smith C, Chacona M, and Brown A*. Osteopontin/secreted phosphoprotein-1: a homeostatic sensor and regulator at the neuro-immune axes. Invited review for Immunological Reviews 2022. http://doi.org/10.1111/imr.13081
  25. Thomas H, Kamkwalala AR, Nath A, McArthur J, Wojna V, Bruce Shiramizu B, Sacktor N, Pardo CA, Haughey N, Clements J, Mankowski J, Zink C, Steiner J, Pomper M, Chang L, Ances B, Hauser K, Letendre S, Stins M, Nerurkar V, Buch S, Burdo T,Rubin LH, Tsukamoto T, Mikhail Pletnikov, Salas R, Gamaldo C, Dziedzic Pand Brown AM*. Early-Career Research Education Mentoring: A Successful Program in NeuroHIV and Mental Health (TRNAMH) in press Neuroimmune Pharmacology and Therapeutics April 2023. Reports on outcomes of a training program co-directed by me and successfully recompeted three times over a 12-year period.https://doi.org/10.1515/nipt-2023-0009
  26. Robinson JA, Mahmud FJ, Greif E, Toribio M, Zanni MV, Brown AM and TH Burdo. Osteopontin (OPN) is an Integral mediator of interstitial fibrosis in models of HIV infection. Journal of Infectious Disease (2023)228:122-132. Provided heart tissue from humanized mice treated with inhibitory or scrambled anti-OPN aptamers and served on thesis committee providing feedback on the project.
  27. Argandona CL and Brown AM*. Microglial- neuronal crosstalk in chronic viral infection through mTOR, SPP1/OPN and inflammasome pathway signaling. Front. Immunol. (2024) 15: https://doi.org/10.3389/fimmu.2024.1368465.
  28. Loganathan S, Sun M, Lopez CA, Wangui J, Shirmamedova A, Johnson A, Louie P, Pelland Z, Alize-Hunt R, Zhu X, SmithD, Brown AM* Osteopontin knockdown reverses HIV-induced cognitive deficits and influences motivation-related behavior. Brain Behav. Immun. (2026) 131: DOI: 10.1016/j.bbi.2025.106168.

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