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Publications

Peer-reviewed Publications

  1. McAdam, R., Weisbrod, T., Martin, J., Scuderi, J., Brown, A., Cirrilo, J., Bloom, B., and W. R. Jacobs Jr. In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis. Infection and Immunity. 1995;63:1004-1012.
  1. Bange, F-C., Brown, A., and W. R. Jacobs Jr. Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages. Infection and Immunity. 1996;64:1794-1799.
  1. Cheng-Mayer, C., Brown, A., Harouse, J., Luciw, P. A., and A. J. Mayer. Selection for neutralization resistance of the simian/human immunodeficiency virus SHIVSF33A variant in vivo by virtue of sequence changes in the extracellular envelope glycoprotein that modify N-linked glycosylation. J. Virol. 1999;73:5294-5300.
  1. Brown, A., Wang, X., Sawai, E. and C. Cheng-Mayer. Activation of the PAK-related kinase by human immunodeficiency type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complex. J. Virol. 1999;73:9899-9907. First publication to show that HIV Nef interacts with a complex of proteins to enhance virus replication in macrophages.
  1. Braunstein, M., Brown, A., Kurtz, S. and W. R. Jacobs, Jr. Two nonredundant SecA homologues function in mycobacteria. J. Bacteriol. 2001;183:6979-6990. Publication resulting from Dr. Brown’s thesis work. It was the first identification of the central protein required for general protein secretion in mycobacteria.
  1. Brown, A., Moghaddam, S., Kawano, T. and C. Cheng-Mayer. Multiple human immunodeficiency type 1 Nef functions are required for efficient replication in primary human macrophages. J. Gen. Virol. 2004;85:1451-1461.
  1. Brown, A., Gartner, S., Kawano, T., Benoit, N. and C. Cheng-Mayer. HLA-A2 down-regulation on primary human macrophages infected with a M-tropic EGFP-tagged HIV-1 reporter virus. J. of Leukocyte Biol. 2005;78:675-685. Publication of the first macrophage-tropic replication competent HIV reporter virus encoding all of the viral proteins.
  1. Brown, A., Zhang, H., Lopez, P., Pardo, C. and S. Gartner. In vitro modeling of the HIV-macrophage reservoir. J. of Leukocyte Biol. 2006;80:1127-1135. First report to identify and characterize at the molecular level latent and persistent populations of HIV-infected macrophages.
  1. Brown, A., Use of a macrophage-tropic GFP-tagged human immunodeficiency virus type 1 (HIV-1) to study viral reservoirs. Methods in Mol. Biol 2009;515:165-175.
  1. Grab, D, Garcia-Garcia, J. C., Nikolskaia, O V., Kim, Y. V., Brown, A., Pardo, C. A., Zhang, Y., Becker, K. G., Wilson, B. A., de A Lima, A P., Scharfstein, J., and J. S. Dumler. Protease activated receptor signaling is required for African typanosome traversal of human brain microvascular endothelial cells. PLOS Neglected Tropical Diseases 2009: 3(7):e479. Isolated trypanosome infected human brain microvascular endothelial cells using laser capture microdissection.
  2. Hammoud DA, Endres C.J., Hammond E., Uzuner O., Brown A., Nath A., Kaplin A.I., Pomper M.G. Imaging serotonergic transmission with [(11)C]DASB-PET in depressed and non-depressed patients infected with HIV. Neuroimage 2009; 49:2588-2595. Performed genotyping of the serotonin transporter.
  1. Brown, A*., Islam, T., Adams, R., Nerle, S., Kamara, M., Eger, C., Marder, K., Cohen, B., Schifitto, G., McArthur, J., Sacktor, N., and C. Pardo. 2011. Osteopontin enhances HIV-1 replication and is increased in the brain and cerebrospinal fluid of HIV-infected individuals. J. Neurovirology 17:382-392. *Corresponding author.
  1. Brown, A*., Sacktor, N., Marder, K., Cohen, B., Schifitto, G., Skolasky, R., Creighton, J., Guo, L and J. McArthur. 2012. CCL3L1 gene copy number in individuals with and without HIV-associated neurocognitive disorder. Current Biomarker Findings 2: 1-6. *Corresponding author.
  1. Brown, A. 2012. Osteopontin: a key link between immunity, inflammation and the central nervous system. Translational Neuroscience 3(3): 288-293.
  1. Gamaldo, C.E., Gamaldo, A., Creighton, J., Salas, RE., Selnes, OA., David, PM., Mbeo, G., Parker, BS., Brown, A., McArthur, JC., Smith, MT. 2013. Sleep and cognition in an HIV+ cohort: a multi-method approach. J. Acquir. Immune Defic. Syndr (Epub May 2013).
  1. Lucas, C-H, Calvez, M., and A. Brown. 2013. Altered subcellular localization of the NeuN/Rbfox3 RNA splicing factor in HIV-associated neurocognitive disorders (HAND). Neuroscience Letters 558:97-102 (ePub October 13, 2013).
  1. Babu, R. and A. Brown. 2013. A consensus surface activation marker signature is partially dependent on human immunodeficiency Virus Type I Nef expression within productively infected macrophages. Retrovirology 10:155.
  1. Lucas, C-H, Calvez, M., and A. Brown. 2014. Altered subcellular localization of the NeuN/Rbfox3 RNA splicing factor in HIV-associated neurocognitive disorders (HAND). Neuroscience Letters 558:97-102 (ePub October 13, 2013). First study to report a unique observation on the neuron-specific marker NeuN in brain tissue from HIV-infected subjects with cognitive impairment.
  1. Eger, C., Cirelli, K., Budiaman, J., and A. Brown. 2014. Non-continguous protein interaction domains in osteopontin contribute to enhance HIV-1 replication. J. Human Virol. and Retrovirol 1(1):00003. First report on the molecular genetic analyses to map osteopontin functional domains.
  1. Silva, K., Hope-Lucas, C., White, T., Hariston, T., Rameau, T., and A. Brown. 2015. Cortical neurons are a prominent source of the proinflammatory cytokine osteopontin in HIV-associated neurocognitive disorders (HAND). J. Neurovirology 21:174-185. First quantitative analyses of osteopontin expression on human brain autopsy tissue. 

20. Brown, A. 2015. Understanding the MIND phenotype: macrophage/microglial inflammation in  neurocognitive disorders related to human immunodeficiency virus infection. Clinical Translational Medicine 4:7 DOI 10.1186/s40169-015-0049-2.


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