Peer-reviewed Publications
- McAdam, R., Weisbrod, T., Martin, J., Scuderi, J., Brown, A., Cirrilo, J., Bloom, B., and W. R. Jacobs Jr. In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis. Infection and Immunity. 1995;63:1004-1012.
- Bange, F-C., Brown, A., and W. R. Jacobs Jr. Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages. Infection and Immunity. 1996;64:1794-1799.
- Cheng-Mayer, C., Brown, A., Harouse, J., Luciw, P. A., and A. J. Mayer. Selection for neutralization resistance of the simian/human immunodeficiency virus SHIVSF33A variant in vivo by virtue of sequence changes in the extracellular envelope glycoprotein that modify N-linked glycosylation. J. Virol. 1999;73:5294-5300.
- Brown, A., Wang, X., Sawai, E. and C. Cheng-Mayer. Activation of the PAK-related kinase by human immunodeficiency type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complex. J. Virol. 1999;73:9899-9907. First publication to show that HIV Nef interacts with a complex of proteins to enhance virus replication in macrophages.
- Braunstein, M., Brown, A., Kurtz, S. and W. R. Jacobs, Jr. Two nonredundant SecA homologues function in mycobacteria. J. Bacteriol. 2001;183:6979-6990. Publication resulting from Dr. Brown’s thesis work. It was the first identification of the central protein required for general protein secretion in mycobacteria.
- Brown, A., Moghaddam, S., Kawano, T. and C. Cheng-Mayer. Multiple human immunodeficiency type 1 Nef functions are required for efficient replication in primary human macrophages. J. Gen. Virol. 2004;85:1451-1461.
- Brown, A., Gartner, S., Kawano, T., Benoit, N. and C. Cheng-Mayer. HLA-A2 down-regulation on primary human macrophages infected with a M-tropic EGFP-tagged HIV-1 reporter virus. J. of Leukocyte Biol. 2005;78:675-685. Publication of the first macrophage-tropic replication competent HIV reporter virus encoding all of the viral proteins.
- Brown, A., Zhang, H., Lopez, P., Pardo, C. and S. Gartner. In vitro modeling of the HIV-macrophage reservoir. J. of Leukocyte Biol. 2006;80:1127-1135. First report to identify and characterize at the molecular level latent and persistent populations of HIV-infected macrophages.
- Brown, A., Use of a macrophage-tropic GFP-tagged human immunodeficiency virus type 1 (HIV-1) to study viral reservoirs. Methods in Mol. Biol 2009;515:165-175.
- Grab, D, Garcia-Garcia, J. C., Nikolskaia, O V., Kim, Y. V., Brown, A., Pardo, C. A., Zhang, Y., Becker, K. G., Wilson, B. A., de A Lima, A P., Scharfstein, J., and J. S. Dumler. Protease activated receptor signaling is required for African typanosome traversal of human brain microvascular endothelial cells. PLOS Neglected Tropical Diseases 2009: 3(7):e479. Isolated trypanosome infected human brain microvascular endothelial cells using laser capture microdissection.
- Hammoud DA, Endres C.J., Hammond E., Uzuner O., Brown A., Nath A., Kaplin A.I., Pomper M.G. Imaging serotonergic transmission with [(11)C]DASB-PET in depressed and non-depressed patients infected with HIV. Neuroimage 2009; 49:2588-2595. Performed genotyping of the serotonin transporter.
- Brown, A*., Islam, T., Adams, R., Nerle, S., Kamara, M., Eger, C., Marder, K., Cohen, B., Schifitto, G., McArthur, J., Sacktor, N., and C. Pardo. 2011. Osteopontin enhances HIV-1 replication and is increased in the brain and cerebrospinal fluid of HIV-infected individuals. J. Neurovirology 17:382-392. *Corresponding author.
- Brown, A*., Sacktor, N., Marder, K., Cohen, B., Schifitto, G., Skolasky, R., Creighton, J., Guo, L and J. McArthur. 2012. CCL3L1 gene copy number in individuals with and without HIV-associated neurocognitive disorder. Current Biomarker Findings 2: 1-6. *Corresponding author.
- Brown, A. 2012. Osteopontin: a key link between immunity, inflammation and the central nervous system. Translational Neuroscience 3(3): 288-293.
- Gamaldo, C.E., Gamaldo, A., Creighton, J., Salas, RE., Selnes, OA., David, PM., Mbeo, G., Parker, BS., Brown, A., McArthur, JC., Smith, MT. 2013. Sleep and cognition in an HIV+ cohort: a multi-method approach. J. Acquir. Immune Defic. Syndr (Epub May 2013).
- Lucas, C-H, Calvez, M., and A. Brown. 2013. Altered subcellular localization of the NeuN/Rbfox3 RNA splicing factor in HIV-associated neurocognitive disorders (HAND). Neuroscience Letters 558:97-102 (ePub October 13, 2013).
- Babu, R. and A. Brown. 2013. A consensus surface activation marker signature is partially dependent on human immunodeficiency Virus Type I Nef expression within productively infected macrophages. Retrovirology 10:155.
- Lucas, C-H, Calvez, M., and A. Brown. 2014. Altered subcellular localization of the NeuN/Rbfox3 RNA splicing factor in HIV-associated neurocognitive disorders (HAND). Neuroscience Letters 558:97-102 (ePub October 13, 2013). First study to report a unique observation on the neuron-specific marker NeuN in brain tissue from HIV-infected subjects with cognitive impairment.
- Eger, C., Cirelli, K., Budiaman, J., and A. Brown. 2014. Non-continguous protein interaction domains in osteopontin contribute to enhance HIV-1 replication. J. Human Virol. and Retrovirol 1(1):00003. First report on the molecular genetic analyses to map osteopontin functional domains.
- Silva, K., Hope-Lucas, C., White, T., Hariston, T., Rameau, T., and A. Brown. 2015. Cortical neurons are a prominent source of the proinflammatory cytokine osteopontin in HIV-associated neurocognitive disorders (HAND). J. Neurovirology 21:174-185. First quantitative analyses of osteopontin expression on human brain autopsy tissue.
20. Brown, A. 2015. Understanding the MIND phenotype: macrophage/microglial inflammation in neurocognitive disorders related to human immunodeficiency virus infection. Clinical Translational Medicine 4:7 DOI 10.1186/s40169-015-0049-2.